Figure 3.
Stress reduces synaptic excitability. (A) Representative sEPSC traces from each male rat group. (B) Representative sEPSC traces from each female rat group. (C) Quantification of stress effects on sEPSC amplitude. Bars show the mean sEPSC amplitude in control (black) and stressed (gray) rats. Stress significantly reduced sEPSC amplitude in males (F1,68 = 5.6, P = 0.02) and females (F1,86 = 28.1, P < 0.0001). Vertical lines indicate standard error of the mean (SEM). *P < 0.05 post hoc Tukey's HSD. Male EA control (n = 11), Male EA stress (n = 16), Male MA control (n = 9), Male MA stress (n = 10), Male Adult control (n = 12), Male Adult stress (n = 12), Female EA control (n = 17), Female EA stress (n = 16), Female MA control (n = 14), Female MA stress (n = 12), Female Adult control (n = 12), Female Adult stress (n = 16).