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. 2015 Oct 27;27(1):625–634. doi: 10.1093/cercor/bhv241

Figure 7.

Figure 7.

Blockade of striatal GABA-A receptors in naïve rats fully reproduced the pattern of LFP disinhibition induced by chronic DA lesion. (a) Relative to aCSF (naïve + aCSF; n = 8), striatal infusion of the GABA-A receptor antagonist picrotoxin (100 μM) in naïve rats (naïve + picrotoxin; n = 8) resulted in LFP disinhibition at 10 Hz (main effect of treatment: F1,140 = 104.2, P < 0.0005; *P < 0.05/**P < 0.005/***P < 0.0005 vs. naïve + aCSF, +P < 0.05/++P < 0.005/+++P < 0.0005 vs. 1st pulse, LSD post hoc test, two-way ANOVA) that resembles the response pattern seen in rats with >90 DA lesion (black line). (b) A similar LFP disinhibition was observed at 20 Hz following striatal infusion of picrotoxin in naïve rats (main effect of treatment: F1,140 = 67.4, P < 0.0005; *P < 0.05/**P < 0.005 vs. naïve + aCSF, +P < 0.05/++P < 0.005/+++P < 0.0005 vs. 1st pulse, LSD post hoc test, two-way ANOVA). (c) Striatal infusion of picrotoxin in naïve rats also resulted in marked attenuation of the evoked LFP inhibition at 40 Hz (main effect of treatment: F1,140 = 109.1, P < 0.0005; *P < 0.05/***P < 0.0005 vs. naïve + aCSF, +++P < 0.0005 vs. 1st pulse, LSD post hoc test, two-way ANOVA). (d) Summary of the mean LFP response calculated from pulses 2 to 10 (*P < 0.05/**P < 0.005 vs. naïve + aCSF, LSD post hoc test, one-way ANOVA; 10 Hz: F2,26 = 4.0, P < 0.05, 20 Hz: F2,26 = 6.5, P < 0.005, 40 Hz: F2,26 = 9.3, P < 0.005).