Fig. 4.

A Heatmap of -log10-transformed P-values for all 32 significant CP:KEGG pathways selected by FUNNEL (ordered by adjusted Fisher’s P-values for the symptomatic group). The P-values computed from individual subjects were combined by Fisher’s combined probability test in each group. Bonferroni procedure for multiple testing adjustment was applied to the combined Fisher’s P-values to control for FWER. Many of these pathways listed here, such as the B-, T-cell receptor signaling, NOD-like signaling, RIG-like receptor signaling, Toll-like receptor signaling, Chemokine signaling, JAK-STAT signaling, FC-Epsilon-RI signaling, MTOR signaling pathways are well documented immune signaling pathways that send signals that lead to the activation of various cell-specific immune activities (Color version of this figure is available at Bioinformatics online.)