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. Author manuscript; available in PMC: 2018 May 8.
Published in final edited form as: Biochemistry. 2016 Jun 2;55(23):3261–3269. doi: 10.1021/acs.biochem.6b00510

Figure 1.

Figure 1

Thymidylate synthase chemical mechanisms. (a) the mechanism for classic TS using an enzymatic cysteine-nucleophile.1 (b) a proposed mechanism for FDTS using an electrostatically polarizing active site to activate dUMP.6