Table 2.
Post-diagnostic marine ω-3 PUFA intake in relation to cancer recurrence and survival among 1,011 stage III colon cancer patients
| Quartile of marine ω-3 PUFAs
|
Ptrenda | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | ||
| No. at risk | 252 | 253 | 253 | 253 | |
| Disease-free survivalb | |||||
| Events | 112 | 101 | 88 | 85 | |
| Model 1 HR (95% CI)c | 1.00 | 0.88 (0.67–1.15) | 0.77 (0.58–1.02) | 0.73 (0.55–0.97) | 0.03 |
| Model 2 HR (95% CI)d | 1.00 | 0.84 (0.64–1.10) | 0.74 (0.56–0.98) | 0.72 (0.54–0.97) | 0.03 |
| Recurrence-free survivalb | |||||
| Events | 96 | 95 | 81 | 71 | |
| Model 1 HR (95% CI)c | 1.00 | 0.95 (0.72–1.26) | 0.83 (0.62–1.11) | 0.71 (0.52–0.96) | 0.02 |
| Model 2 HR (95% CI)d | 1.00 | 0.91 (0.68–1.21) | 0.78 (0.58–1.05) | 0.70 (0.51–0.96) | 0.02 |
| Overall survival | |||||
| Events | 88 | 81 | 68 | 68 | |
| Model 1 HR (95% CI)c | 1.00 | 0.91 (0.66–1.26) | 0.69 (0.49–0.98) | 0.79 (0.56–1.10) | 0.13 |
| Model 2 HR (95% CI)d | 1.00 | 0.86 (0.62–1.19) | 0.68 (0.48–0.96) | 0.81 (0.58–1.15) | 0.23 |
P-trend calculated by modeling the median of each category as a continuous term.
Disease-free survival = time from the baseline FFQ to tumor recurrence, occurrence of a new primary colon tumor, or death from any cause, whichever came first. Recurrence-free survival =time from the baseline FFQ to tumor recurrence or occurrence of a new primary colon tumor; patients who died without known recurrence were censored at last evaluation.
Cox proportional hazards regression model adjusted for age, sex, and energy intake.
Cox proportional hazards regression model adjusted for variables in Model 1 plus T-stage, number of positive lymph nodes, baseline performance status, treatment arm, body mass index, physical activity, smoking, and aspirin use.