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Binding mode of pyrrolo[3,4-c]pyrazol inhibitors. a) Binding mode typical for type I kinase inhibitors, including the interactions with the hinge region and the hydrophobic pockets I and II. b) Co-crystal structure of PHA-680632 and the HsAURKA catalytic domain. Ribbon color indicates the type of secondary structure; red = α-helix, yellow = β-sheet, white = disordered.24 PDBID: 2J50.
