Figure 4.

Effect of SB on joint tissue in control and experimental rats as determined by H & E staining (400× magnification). Control rats exhibited a normal articular cartilage architecture without mononuclear cell or PMN infiltration (A). CIA rats showed diffuse PMN infiltration with articulated cartilage erosion and synovitis (arrow, B). Rats treated with 20 mg/kg SB showed mild PMN infiltration with slight cartilage erosion and synovitis (C). Rats treated with 40 mg/kg SB showed almost normal articular cartilage without erosion but with infiltration by a few PMNs and inflammation (synovitis) (D). Scale bar, 50 μm.