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. 2017 Dec 22;217(7):1145–1152. doi: 10.1093/infdis/jix651

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© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Figure 3. — Population preexisting antibody responses are less robust for GII.4 2015 as compared to GII.4 2012. Archived sera collected between 2014 and 2016 from healthy blood donors were evaluated for blockade of GII.4 2012 and GII.4 2015 virus-like particle binding to ligand. The mean percentage of control binding as compared to no antibody was fit with sigmoidal dose-response curve analysis, and half-maximal effective concentrations (EC₅₀ values) were calculated. CI, confidence interval. *P < .05, by the Wilcoxon test, compared with GII.4 2012.