Figure 4.
Epitope mapping of GII.4 2012 monoclonal antibodies (mAbs). mAbs to GII.4 2012 were evaluated for reactivity to a panel of virus-like particles with mutations in epitopes A and D in GII.4 2012, to map binding residues. Five mAbs recognize epitope A. Three anchor at residue 373 (orange) and 2 at 368 (green). 2012.G8 recognizes a novel cross-reactive undefined epitope H (blue). The epitope for 2012.G2 is undetermined (gray). Ab, antibody; CI, confidence interval; EC50, half-maximal effective concentration.