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. 2017 Dec 22;217(7):1145–1152. doi: 10.1093/infdis/jix651

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© The Author(s) 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

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Figure 5. — GII.4 2015 is antigenically distinguishable from GII.4 2012 at multiple blockade antibody epitopes. Monoclonal antibodies (mAbs) to GII.4 2012 were evaluated for the blockade potency of GII.4 2012 (closed circles) and GII.4 2015 (open circles) binding to ligand. The mean percentage of control binding as compared to no antibody was fit with sigmoidal dose-response curve analysis, and half-maximal effective concentrations (EC₅₀ values) were calculated. Blockade potency was severely diminished for mAbs that anchor on residue 373 of epitope A (orange) and epitope H (blue) and were reduced for mAbs that anchor on residue 368 (green). The epitope for 2012.G2 is undetermined (gray). Error bars represent the 95% confidence intervals. *P < .05, by an unpaired t test with the Welch correction, compared with GII.4 2012.