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Changes in epitope D of GII.4 2015 alter blockade antibody binding. GII.4 2012 and 2015 virus-like particles were evaluated for blockade of ligand binding by human monoclonal antibody (mAb) to epitope D, NVB 97. The mean percentage of control binding as compared to no antibody was fit with sigmoidal dose-response curve analysis. SEM, standard error of the mean.
