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ERAP2 genotype and protein expression in cell lines.
| Cell | SNP rs2248374 | SNP rs2549782 | ERAP2 without |
|---|---|---|---|
| line | (A/G) | (G/T) | IFNγ/with γ |
| BeWo | GG | TT | ND/ND |
| JAr | AG | GT | ND/++ (*P = 0.0233) |
| JEG-3 | GG | TT | ND/ND |
| T3M-3 | AG | GT | ND/+ (*P = 0.0127) |
ND = not detected.
ERAP2 protein is not detected until cells are stimulated with IFNγ. Cell lines that are heterozygous for SNP rs2248374 produce detectable levels of ERAP2 protein.
