Figure 1.

Scheme of animal models and experimental design. Female PXR^−/−ApoE^−/− mice (F0) were mated with male huPXR•ApoE^−/− mice. The pregnant female PXR^−/−ApoE^−/− mice were fed a control diet or BPA diet until the pups were weaned on P21. The weaned offspring were fed a control diet until euthanization at 16 weeks of age. IPGTT, intraperitoneal glucose tolerance test.