Table 1.

Extended half-life FVIII products. Mean half-lives are given for patients > 12 years only^a

Generic name	Name	Technology	Cell line	Molecule length	Mean half-life, h
Efmoroctocog alfa	Elocta®	Fc-fusion	HEK	BDD	19
Rurioctacog alfa pegol	Adynovi®	PEGylation to surface exposed lysine	CHO	full-length	14–16
Turoctocog alfa pegol	-	single site-specific PEGylation to O-linked glycan in B-domain	CHO	BD truncated	19
Damoctocog alfa pegol	-	site-specific PEGylation to cysteine1805	BHK	full-length	19
Lonoctocog alfa	Afstyla®	covalently linked heavy and light chain with increased affinity for vWF	CHO	BDD	14.5

HEK = Human embryonic kidney; CHO = Chinese hamster ovary; BHK = baby hamster kidney; vWF = von Willebrand Faktor; BDD = B-domain deleted; BD = B-domain.

^aNote that methods to evaluate half-lives differed among studies.