Fig. 4.

a Photomicrograph of orbital extension of frontal lobe malignant meningioma demonstrating margin between tumor tissue that is viable (lower right side) and necrotic (upper left side, labeled). HE. Original magnification ×125. b Higher-magnification photomicrograph of orbital meningioma demonstrating pleomorphic tumor cells with large vesicular nuclei and prominent nucleoli, including 2 abnormal mitoses (arrows). HE. Original magnification ×500. c Photomicrograph of IHC somatostatin-2 which is highly positive in the orbital lesion and consistent with meningioma. Somatostatin receptor type 2. Original magnification ×125. d Photomicrograph of lung metastasis biopsy (CT core sample) from left lung including the margin of pulmonary tissue (PT) on the right. HE. Original magnification ×125. The inset at higher magnification (HE; original magnification ×500) demonstrates an area of the same biopsy with histologic characteristics similar to those in the orbital lesion.