Table 1.

Sex Differences in Comparative Pharmacotherapy Efficacy

	Sex difference interaction effect size (women vs. men [reference]) [risk ratio (95% CI)]	p
Head-to-head comparisons
Varenicline vs. TN	1.19 (1.01, 1.40)	.04
Varenicline vs. bupropion SR	1.22 (1.02, 1.47)	.03
Bupropion SR vs. TN	0.97 (0.79, 1.19)	.77
Comparisons to placebo
Varenicline vs. Placebo	1.01 (0.86, 1.19)	.89
TN vs. Placebo	0.85 (0.71, 1.02)	.08
Bupropion SR vs. Placebo	0.83 (0.68, 1.01)	.06

CI = confidence interval; SR = sustained release; TN = Transdermal nicotine. p-values < .05 were considered statistically significant.