Table 1.
Clinical characteristics of patients with frontal fibrosing alopecia and concomitant lichen planopilaris
| Present study | Vañó-Galván et al. [4] | Meinhard et al. [9] | Soares et al. [10] | |
|---|---|---|---|---|
| Cases, n | 17 | 355 | 104 | 80 |
| Type of alopecia | FFA and LPP: 17 (100%) | FFA: 355 (100%) | FFA: 32 (30.8%) LPP: 71 (68.2%) GLPLS: 1 (1%) | FFA: 29 (36.3%) LPP: 50 (62.5%) GLPLS: 1 (1.2%) |
| Age of onset of alopecia (range), years | 63.9 (43–82) | 56 (21–81) | Women: 58 years Men: 52 years | ns |
| Median grade of severity of FFAa | III (3–4.99 cm) | II (1–2.99 cm) | ns | ns |
| Clinical presentation of LPP | Random plaques: 15 (88.2%) Vertex involvement: 2 (11.8%) | na | ns | Random plaques: 24 (30%) FAPD: 29 (36.3%) Vertex involvement: 4 (5%) |
| Pruritus | 11 (64.7%) | 124 (35%) | ns | ns |
| Pain | 7 (41.2%) | 71 (20%) | ns | ns |
| Occipital involvement | 4 (23.5%) | 52 (15%) | ns | ns |
| Eyebrow loss | 15 (88.2%) | 283 (80%) | FFA: 19 (59.4%) LPP: 5 (7%) | ns |
| Eyelash loss | 7 (41.2%) | 50 (14%) | ns | 3 (3.8%) |
| Facial papules | 6 (35.3%) | 49 (14%) | ns | ns |
| Body hair involvement | Axillary hair: 8 (47.1%) Pubic hair: 7 (41.2%) Upper and/or lower limbs: 8 (47.1%) | Axillary hair: 75 (21%) Pubic hair: 63 (18%) Upper and/or lower limbs: 86 (24%) | Axillary hair and/or pubic hair: FFA: 5 (15.6%) LPP: 6 (8.5%) | Axillary hair: 16 (20%) Pubic hair: 8 (10%) Upper and/or lower limbs: 9 (11.3%) |
| Mucosal abnormalities | Mucosal LP: 4 (23.5%; 3 reticular form and 1 erosive form) | Mucosal LP: 12 (3.4%) | ns | Mucosal LP: 2 (2.5%; 1 in FFA patient) |
| Nail abnormalities | Pterygium nail: 1 (5.9%) | ns | ns | Pterygium nail: 2 (2.5%; in a FFA patient) Involvement 20 nails: 1 (1.25%) |
| Other cutaneous disorders | Rosacea: 8 (47.1%) Nickel contact dermatitis: 3 (17.6%) Vasculitis: 1 (5.9%) Seborrheic dermatitis: 1 (5.9%) | Cutaneous LP: 23 (6.5%) Vitiligo: 2 (0.6%) Alopecia areata: 2 (0.6%) LSA: 1 (0.3%) LPP: 3 (0.8%) AGA: 150 (42.3%) | FFA Vitiligo: 2 (6.3%) Alopecia areata: 1 (3.1%) LPP Cutaneous LP: 4 (5.6%) Seborrheic dermatitis: 3 (4.2%) Alopecia areata: 1 (1.4%) | Cutaneous LP: 2 (2.5%) |
Values are n (%) unless otherwise specified. AGA, androgenetic alopecia; FAPD, frontal alopecia in a pattern distribution; FFA, frontal fibrosing alopecia; GLPLS, Graham-Little Piccardi-Lassueur syndrome; LPP, lichen planopilaris; LP, lichen planus; LSA, lichen sclerosus et atrophicus. ns, not specified; na, not applicable.
a
Scale of severity of FFA by Vañó-Galván et al. [4].