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Increased virulence of acapsular and hyperhemolytic group B streptococci (GBS). Wild-type (WT) C57BL6/J mice (n = 20/group, A) or NLRP3 knockout (KO) mice (n = 14/group, B) were infected intravenously with GBS (WT, ΔcovR, ΔcovRΔcpsE, or ΔcpsE). Gehan–Breslow–Wilcoxon test was used to compare Kaplan–Meier survival curves. A, **P = .009, ***P = .0009, ****P < .0001; survival of mice infected with GBS WT compared to ΔcpsE was not significantly different (P = .3). B, *P = .04, **P = .005.
