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. 2018 Feb 1;217(7):1024–1032. doi: 10.1093/infdis/jix662

Figure 1.

Figure 1.

Serum and cerebrospinal fluid (CSF) human immunodeficiency virus (HIV) antibody levels in patients with chronic HIV infection before and after long-term treatment. Antibody measurements were made in (A) serum and (B) CSF samples taken from before and after long-term treatment of subjects with chronic HIV infection and uninfected controls. The y axis reflects the antibody levels in light units determined by luciferase immunoprecipitation systems. The total HIV antibody levels were derived from the sum of antibody values against 7 antigens. The geometric mean antibody levels and 95% confidence interval are shown for each group. The geometric mean level in the chronic HIV-infected participants after treatment was further used as reference for Figure 2. The black dotted line is the cutoff value, based on the uninfected controls, for determining seropositivity of the combined antibody total for serum and CSF. Wilcoxon rank statistical analysis was used to statistically evaluate differences between the paired before and after treatment samples. Abbreviations: ART, antiretroviral therapy.