Figure 2.

Serum and cerebrospinal fluid (CSF) antibody levels in untreated and treated early human immunodeficiency virus (HIV) infection. Untreated subjects with early HIV infection were evaluated for (A) serum and (B) CSF antibodies in paired cross-sectional and longitudinal samples. Similarly, treated subjects with early HIV infection were evaluated for (C) serum and (D) CSF antibodies in paired cross-sectional and longitudinal samples. Each colored dot reflects an individual subject. An open circle reflects the absence of antiretroviral therapy at that time point. The black dotted line is the cutoff value for determining seropositivity and is based on the uninfected controls of the combined antibody total for serum and CSF. As a reference, the blue dotted line represents the geometric mean antibody levels found in the corresponding serum and CSF of the treated chronically infected subjects. The serum and CSF antibody values for the Berlin patient (red solid dot) are also shown. Abbreviations: LU, light units.