Table 1.
Subject Characteristics (At First Visit)
| Subject Groups | N | Site (SF/GOT) Ratio | Gender (M/F) Ratio | Age (Years) | Time Since Infection (Years) | CD4 (Cells/μL) | Plasma HIV RNA | CSF HIV RNA | CSF WBC (per μL) | CSF Neopterin (nMol/L) | CSF/Blood Albumin Ratio Mean (SD) | CSF NFL (Log10 ng/L) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (Log10 Copies/mL) | ||||||||||||
| Mean (SD) | Median (IQR) | |||||||||||
| Chronic infection | 10 | 10:0 | 7:3 | 40.2 ± 8.3 | ? | 137.6 ± 98.7 | 4.38 ± 0.49 | 3.55 ± 0.56 | 1.5 (2.8–11.3) | 24.9 ± 10.5 | 6.1 ± 2.2 | 2.84 ± 0.29 |
| Primary infection | 4.8 ± 1.9 | 2.78 + 0.14 | ||||||||||
| No treatment | 12 | 8:3:1* | 12:0 | 40.1 ± 10.0 | 0.09 ± 0.02 | 608.8 ± 152.0 | 4.17 ± 1.50 | 2.80 ± 1.17 | 3.5 | 10.2 ± 9.2 | 5.0 ± 2.0 | 2.74 ± 0.28 |
| Treatment | 8 | 2:6 | 7:1 | 48.3 ± 9.7 | 0.14 ± 0.10 | 807.8 ± 413.4 | 1.63 ± 0.22 | 1.66 ± 0.05 | 0 | 5.8 ± 1.9 | 5.8 ± 1.9 | 2.64 ± 0.20 |
| Hyperacute | 2 | 2:0 | 2:0 | 42.0 ± 17.0 | 0.20 ± 0.04 | 1059 ± 636.4 | 1.59 ± 0 | 1.59 ± 0 | 5.5 (0–12.5) | 11.1 ± | 4.6 ± 0.9 | 3.48 ± 0.54 |
| Berlin | 1 | 1:0 | 1:0 | 50 | 16.31 | 364 | 5.46 ± 0.44 | 4.91 ± 0.47 | 0 | 4.5 | 9.7 | 4.5 |
| HIV negative | 12 | 12:0 | 7:5 | 48.8 ± 19.6 | NA | NA | NA | NA | 0 | NA | 7.1 ± 4.0 | 2.56 ± 0.26 |
Abbreviations: CSF, cerebrospinal fluid; GOT, Gothenburg; HIV, human immunodeficiency virus; IQR, interquartile range; NA, not applicable; NFL, neurofilament light; RNA, ribonucleic acid; SD, standard deviation; SF, San Francisco; WBC, white blood cells.
*Yale.