Table 2.
SF-6D utility scores for CCSS survivors by number and severity of chronic conditions *
| Characteristic | No. | SF-6D Mean (95% CI) | Compared with no conditions |
|
|---|---|---|---|---|
| P † | Met MID ‡ criteria? | |||
| No conditions | 1475 | 0.809 (0.804 to 0.815) | Reference | Reference |
| No. of conditions, grades 1-4 | ||||
| 1 | 1538 | 0.795 (0.789 to 0.800) | <.001 | No |
| 2 | 1113 | 0.772 (0.765 to 0.779) | <.001 | Yes |
| ≥3 | 2979 | 0.735 (0.729 to 0.739) | <.001 | Yes |
| No. of conditions, grades 3-4 only § | ||||
| 1 | 286 | 0.785 (0.771 to 0.798) | <.001 | No |
| 2 | 518 | 0.725 (0.713 to 0.736) | <.001 | Yes |
| ≥3 | 198 | 0.695 (0.677 to 0.713) | <.001 | Yes |
| Maximum severity of condition(s) ‖ | ||||
| Grade 1 | 1532 | 0.777 (0.771 to 0.782) | <.001 | No |
| Grade 2 | 1623 | 0.772 (0.766 to 0.778) | <.001 | Yes |
| Grade 3 | 1604 | 0.746 (0.739 to 0.752) | <.001 | Yes |
| Grade 4 | 871 | 0.727 (0.718 to 0.736) | <.001 | Yes |
*Childhood Cancer Survivor Study reported health conditions were graded by severity based on the Common Terminology Criteria for Adverse Events (CTCAE version 4.03) as follows: grade 1 (mild), grade 2 (moderate), grade 3 (severe or disabling), and grade 4 (life-threatening) ( 12 ). CCSS = Childhood Cancer Survivor Study; CI = confidence interval; MID = minimally important difference; SF-6D = Short Form-6D.
† P values based on Welch’s two-sided t test.
‡Defined as a .03-point difference in SF-6D score compared with survivors with no conditions.
§Individuals may have also reported grade 1 or 2 conditions.
‖For individuals who had more than one condition, severity was based on maximum grade.