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. Author manuscript; available in PMC: 2019 Jan 1.
Published in final edited form as: Cell Signal. 2017 Feb 4;41:82–88. doi: 10.1016/j.cellsig.2017.02.002

Figure 3.

Figure 3

Properties of OR51E2 expressed on human airway smooth muscle. (A) Cytoskeletal remodeling in HASM is inhibited by OR51E2 agonists. Shown are representative trajectory maps of unforced ferrimagnetic beads attached to HASM using SNTM methodology (see text). Acetate and propionate, but not formate or butyrate, inhibited spontaneous cytoskeletal motions of HASM. (B) EdU incorporation reveals that propionate decreases HASM proliferation. EdU-positive nuclei are labeled with Alexa Fluor 647 (purple color) while all nuclei are labeled with DAPI (blue color). Shown is a representative study. (C) HASM proliferation is inhibited by OR51E2 agonists acetate and proprionate (n = 4 experiments). *, p < 0.05 vs untreated. (D) Inhibition of HASM cell proliferation by OR51E2 agonists is preserved in cells derived from asthmatic lungs (color code same as in C).