Table 3.

Multivariable Regression Models for Variables Associated with Neurocognitive Performance in HIV-infected Subjects

A. Verbal Comprehension
Variable	Beta	SE (Beta)	P
% CD4+CD38+HLA-DR+a	−1.65	1.24	0.19
sCD14	−10.3	4.39	0.03
HIV duration	−0.05	0.03	0.07
Age	−0.41	0.43	0.35
Sex (male vs. female)	6.06	4.34	0.17
Marijuana use (current use vs. no current use)	−5.87	5.46	0.29
	R2 = 0.36
B. Perceptual Reasoning
Variable	Beta	SE (Beta)	P
% CD4+CD38+HLA-DR+a	0.65	1.26	0.61
sCD14	−0.34	4.47	0.46
HIV duration	−0.03	0.03	0.21
Age	−1.04	0.44	0.02
Sex (male vs. female)	15.63	4.42	0.001
Marijuana use (current use vs. no current use)	0.46	5.93	0.94
	R2 = 0.38
C. Working Memory
Variable	Beta	SE (Beta)	P
% CD4+CD38+HLA-DR+a	0.83	1.34	0.54
sCD14	0.25	4.75	0.96
HIV duration	−0.06	0.03	0.04
Age	−0.05	0.47	0.92
Sex (male vs. female)	−0.82	4.69	0.86
Marijuana use (current use vs. no current use)	6.02	5.91	0.32
	R2 = 0.18
D. Processing Speed
Variable	Beta	SE (Beta)	P
% CD4+CD38+HLA-DR+a	−2.81	1.36	0.047
sCD14	−0.75	4.82	0.88
HIV duration	−0.05	0.03	0.12
Age	−0.19	0.47	0.69
Sex (male vs. female)	−2.71	4.77	0.57
Marijuana use (current use vs. no current use)	11.60	6.0	0.06
	R2 = 0.31
E. Full Scale IQ
Variable	Beta	SE (Beta)	P
% CD4+CD38+HLA-DR+a	−0.91	1.18	0.45
sCD14	−5.00	4.19	0.24
HIV duration	−0.05	0.02	0.03
Age	−0.47	0.41	0.26
Sex (male vs. female)	6.21	4.14	0.26
Marijuana use (current use vs. no current use)	2.77	5.21	0.60
	R2 = 0.34

^a% of CD4+ T-cells expressing CD38 and HLA-DR;

HIV, human immunodeficiency virus; SE, standard error; sCD14, soluble CD14; IQ, intelligence quotient