REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
rat anti-BrdU	Abcam	6326
rabbit monoclonal OLFM4	gift from CST	clone PP7
rabbit polyclonal lysozyme	Thermo	RB-372-A1
rabbit chromogranin A	Abcam	15160
rabbit cleaved Caspase-3	CST	9664
rabbit polyclonal Anti-RFP	Rockland	600-401-379
biotin-conjugated secondary donkey anti-rabbit	ImmunoResearch	711-065-152
biotin-conjugated secondary goat anti-rat	ImmunoResearch	112-065-167
anti-Cpt1a	Abcam	128568
anti-HMGCS2	Sigma	AV41562
anti- alpha tubulin	Santa Cruz	8035
anti- total S6	CST	2217
Chemicals, Peptides, and Recombinant Proteins
Advanced DMEM	Gibco	12491015
DMEM/F12	Gibco	11320033
SMEM	Life Technologies	11380-037
Murine EGF	PeproTech	315-09
Recombinant Murine Noggin	PeproTech	250-38
R-spondin	Sino Biological	50316-M08S
N-acetyl-L-cysteine	Sigma-Aldrich	A9165
N2	Life Technologies	17502001
B27	Life Technologies	17504044
Chir99021	LC Laboratories	04-0004
Y-27632	ApexBio	A3008
JAG-1 protein	AnaSpec	AS-61298
Palmitic acid	Cayman Chemical Company	10006627
Etomoxir	Sigma	E1905
GW501516	LC Laboratories	G-4789
KD3010	Dr. Albert R. La Spada
Tamoxifen	Sigma-Aldrich	T5648-1G
4-Hydroxytamoxifen	Calbiochem	579002
13C-Palmitate	Sigma	605573
13C-Glucose	Sigma	389374
Sunflower Seed Oil	Spectrum	S1929
Deposited Data
RNA sequencing data	GEO repository	GEO: GSE89568
Experimental Models: Organisms/Strains
Cpt1aloxP/loxP	Dr. Peter Carmeliet
Villin-CreERT2	Dr. Sylvie Robine
Lgr5-EGFP-IRES-CreERT2;Rosa26-lacZ	The Jackson Laboratory	008875
Lgr5 -IRES-CreERT2	Dr. Hans Clevers
tdTomatoLSL	The Jackson Laboratory	007909
Oligonucleotides
See Table S1 for Primers for Real-time PCR	Integrated DNA Technologies (IDT)	N/A
Software and Algorithms
FlowJo v10	FlowJo LLC.	https://www.flowjo.com/
GraphPad Prism 7	GraphPad Software	https://www.graphpad.com/scientific-software/prism/
Qlucore Omics Explorer 3.2	Qlucore	https://www.qlucore.com/
Other
In situ hybridization probe for mouse Cpt1a Mm-Cpt1a	Advanced Cell Diagnostics, Inc.	443071
In situ hybridization probe for mouse Hmgcs2 Mm-Hmgcs2	Advanced Cell Diagnostics, Inc.	437141
In situ hybridization probe for mouse Lgr5 Mm-Lgr5	Advanced Cell Diagnostics, Inc.	312171