Table 3. Morbidity validation for DNAm PhenoAge.
| Comorbidity | Disease Free | CHD Risk | Physical Functioning | ||||||
| Sample | Coefficient | P-value | Coefficient | P-value | Coefficient | P-value | Coefficient | P-value | |
| DNAm PhenoAge | |||||||||
| WHI BA23 White | 0.008 | 2.38E-01 | -0.002 | 3.82E-01 | 0.016 | 5.36E-02 | -0.396 | 1.04E-04 | |
| WHI BA23 Black | 0.013 | 6.15E-02 | -0.006 | 2.40E-02 | 0.021 | 2.02E-02 | -0.423 | 4.50E-04 | |
| WHI BA23 Hispanic | 0.024 | 1.64E-02 | -0.004 | 3.67E-01 | 0.033 | 5.07E-02 | -0.329 | 7.37E-02 | |
| WHI EMPC White | 0.031 | 2.95E-07 | -0.026 | 1.63E-02 | 0.023 | 1.89E-01 | -0.361 | 3.81E-05 | |
| WHI EMPC Black | 0.014 | 7.67E-02 | -0.023 | 6.98E-02 | 0.048 | 2.27E-02 | -0.473 | 3.75E-04 | |
| WHI EMPC Hispanic | 0.003 | 7.83E-01 | 0.002 | 9.28E-01 | 0.073 | 1.98E-01 | -0.377 | 6.54E-02 | |
| FHS | 0.022 | 3.93E-07 | -0.034 | 1.59E-03 | 0.028 | 5.47E-06 | -0.016 | 4.60E-01 | |
| NAS | 0.023 | 7.59E-06 | -0.062 | 2.00E-04 | 0.030 | 2.27E-02 | NA | NA | |
| JHS | 0.018 | 1.86E-08 | -0.039 | 5.92E-05 | 0.033 | 4.73E-02 | NA | NA | |
| Meta P-value (Stouffer) | 1.95E-20 | 2.14E-10 | 3.35E-11 | 2.05E-13 | |||||
| DNAmAge Hannum | |||||||||
| WHI BA23 White | 0.007 | 3.90E-01 | -0.003 | 3.48E-01 | 0.013 | 2.36E-01 | -0.399 | 2.90E-03 | |
| WHI BA23 Black | 0.022 | 2.72E-02 | -0.007 | 6.03E-02 | 0.015 | 2.67E-01 | -0.345 | 4.29E-02 | |
| WHI BA23 Hispanic | 0.010 | 4.33E-01 | -0.010 | 6.24E-02 | 0.011 | 6.10E-01 | -0.599 | 1.16E-02 | |
| WHI EMPC White | 0.025 | 1.53E-03 | -0.020 | 1.55E-01 | 0.022 | 3.30E-01 | -0.284 | 1.43E-02 | |
| WHI EMPC Black | 0.022 | 6.34E-02 | -0.008 | 6.62E-01 | 0.055 | 6.12E-02 | -0.323 | 9.56E-02 | |
| WHI EMPC Hispanic | -0.012 | 4.17E-01 | 0.035 | 2.09E-01 | -0.012 | 8.85E-01 | -0.345 | 2.54E-01 | |
| FHS | 0.019 | 5.94E-04 | -0.030 | 2.55E-02 | 0.022 | 1.55E-02 | 0.040 | 1.32E-01 | |
| NAS | 0.009 | 2.19E-01 | -0.026 | 2.26E-01 | 0.025 | 1.83E-01 | NA | NA | |
| JHS | 0.020 | 2.09E-05 | -0.036 | 9.91E-03 | 0.086 | 1.64E-04 | NA | NA | |
| Meta P-value (Stouffer) | 1.50E-08 | 1.64E-04 | 1.40E-05 | 2.03E-05 | |||||
| DNAmAge Horvath | |||||||||
| WHI BA23 White | 0.007 | 3.49E-01 | -0.004 | 1.69E-01 | 0.001 | 9.12E-01 | -0.440 | 5.10E-04 | |
| WHI BA23 Black | 0.018 | 3.96E-02 | -0.006 | 6.25E-02 | 0.009 | 4.07E-01 | -0.305 | 4.52E-02 | |
| WHI BA23 Hispanic | 0.012 | 3.65E-01 | -0.007 | 1.86E-01 | -0.001 | 9.78E-01 | -0.204 | 4.12E-01 | |
| WHI EMPC White | 0.031 | 1.99E-04 | -0.043 | 5.56E-03 | 0.000 | 9.88E-01 | -0.288 | 1.74E-02 | |
| WHI EMPC Black | 0.016 | 1.93E-01 | -0.003 | 8.56E-01 | 0.033 | 2.87E-01 | -0.144 | 4.68E-01 | |
| WHI EMPC Hispanic | -0.025 | 8.99E-02 | -0.016 | 5.70E-01 | -0.064 | 4.63E-01 | -0.012 | 9.70E-01 | |
| FHS | 0.011 | 5.82E-02 | -0.021 | 8.34E-02 | 0.007 | 5.19E-01 | 0.027 | 3.16E-01 | |
| NAS | 0.011 | 7.90E-02 | -0.039 | 4.53E-02 | 0.006 | 7.14E-01 | NA | NA | |
| JHS | 0.014 | 2.03E-03 | -0.040 | 1.78E-03 | 0.049 | 3.93E-02 | NA | NA | |
| Meta P-value (Stouffer) | 3.26E-06 | 6.36E-07 | 1.49E-01 | 1.43E-03 | |||||