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Regulation of tubulin acetylation. α-TAT1 and HDAC6 control the acetylation and deacetylation of Lys40 of α-tubulin, respectively. Paclitaxel treatment increases α-tubulin acetylation by augmenting MT stability, whereas HDAC6 inhibitors (e.g., tubacin) do so by reducing α-tubulin deacetylation. INF2 and other formins affect tubulin acetylation by regulating MT stability and by controlling the levels of α-TAT1 via expression of the α-TAT1 gene.
