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. 2018 Mar 8;8(5):1579–1592. doi: 10.1534/g3.118.200161

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Copyright © 2018 Ghavidel et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Schematic representation of control of vacuolar acidity in aging yeast cells. A working model of an interconnected transcriptional network underlying vacuolar acidity in yeast. Nuclear localization of Hcm1 upregulates the expression of FKH genes in S/G2, which, in turn, induces the expression of VMA vacuolar proton pump genes in cells undergoing early divisions. Hcm1 is no longer restricted to the nucleus in replicatively old cells. This results in reduced expression of VMA genes and the ensuing loss of vacuolar acidity.