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. 2018 Mar 12;8(5):1615–1626. doi: 10.1534/g3.118.200181

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Copyright © 2018 Bronstein et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Analysis the role of Srs2 on induced DNA repair: (A) the sensitization effect of SRS2 requires the HR machinery. (B) A schematic representation of strain MK166, which allows scoring of recombination levels for different substrates. (C) An extra copy of SRS2 reduces the induced levels of GC and DRR in haploids. (D) Diploids are not affected by an extra copy of SRS2. (E)(F) In the background of Δrdh54 or Δrad59 there is less GC and DRR induction, however an extra copy of SRS2 does not show any negative effect on HR repair.