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A model for Srs2 toxicity. (A) Srs2 regulates HR repair by removing Rad51 after invasion of a homologous sequence. This is necessary to allow the annealing of the newly synthesized DNA to the other broken arm. (B)(C) Srs2 activity can inhibit the completion of repair in both SDSA and SSA. This activity of Srs2 does not require interaction with PCNA or with Rad51, and depends only on Srs2’s helicase activity.
