Table 1. Characteristics of four groups of BWHS subjects.
| Lean, healthy | Obese, healthy | Obese, unhealthy, no metformin | Obese, unhealthy, metformin-treated | P-value | |
|---|---|---|---|---|---|
| Group | I | II | III | IV | |
| N | 30 | 30 | 27 | 33 | |
| Mean age, y (SD) | 51.40 (4.10) | 52.03 (4.86) | 53.22 (4.17) | 55.06 (3.66) | 0.003 |
| WHR | 0.76 (0.04) | 0.81 (0.08) | 0.88 (0.07) | 0.85 (0.07) | < 0.001 |
| Median BMI, kg/m2 (range) | 22.07 (19.86–23.94) | 33.97 (30.21–46.91) | 39.09 (30.89–49.53) | 39.32 (30.44–47.16) | < 0.001 |
| HbA1c, % (SD) | 5.71 (0.43) | 5.67 (0.32) | 7.31 (1.95) | 6.86 (0.96) | < 0.001 |
| T2D duration, y | 8.33 (5.55) | 7.30 (5.59) | > 0.050 | ||
| Metformin | 0 | 0 | 0 | 33 | |
| NSAID | 5 | 8 | 12 | 21 | 0.0565* |
Data are means ± SD for normally distributed variables. P-values were computed using ANOVA and χ2 test (*).
Abbreviations: BMI, Body Mass Index; HbA1c, glycated hemoglobin; NSAID, non-steroidal anti-inflammatory; T2D, Type 2 diabetes; WHR, waist to hip ratio.