Fig 2. Loss of ciliary margin-derived BMP4 does not cause overt ASD.
Slit lamp photographs show multiple ASD phenotypes in Bmp4Δ/+ mice, including iris hypoplasia shown in (B), however αCre+; Bmp4fl/fl mice (C) are indistinguishable from controls (A). The total number of eyes examined for each strain is indicated in the table below (D). ASD was characterized as the presence of one or more of the following: iris hypoplasia, iridocorneal adhesion, corneal opacity, corneal neovascularization, displaced pupils, cataracts, microphthalmia, and anophthalmia. One αCre+; Bmp4fl/fl mutant displayed slight pupillary displacement (D), however minor ASD is also occasionally observed in wild-type animals on the C57BL/6J background.