Fig 3. MIC50 in micromolar obtained after testing each of the compounds against seven different M. mycetomatis isolates.

In this figure the compounds are depicted for which the MIC50s were determined. The MIC50 was defined as the concentration for which 50% of tested isolates were completely inhibited in growth. The MIC50 in μM is depicted in orange, brown or green dependent on their activity. The lowest MIC50 was obtaiend for posaconazole, the highest for MMV1030799, MMV659004 and MMV002817. In the blue box, the MIC50 of MMV689244, fenarimol analogue EPL-BS1246 is depicted. For this compound, its MIC ranged from 0.007 to 8 μM, with a MIC50 of 1 μM. Orange MIC50 values indicate low potency, brown MIC50 values indicate intermediate potency and green (<2 μM) indicates high potency.