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. 2018 May 7;150(5):731–750. doi: 10.1085/jgp.201711965

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© 2018 Silverå Ejneby et al.

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Figure 12. — Summary of suggested mechanisms. Proposed binding of four different compounds to the S3/S4 cleft. The positive charge in blue represents R362R (=R1) in the top of S4. The negative charge in red represents the charged group of the four different compounds. For P1 and P3 compounds and for PUFAs, the negative charge is suggested to be attracted to the S4 charge. For P4 compounds, the charge is suggested to be attracted to the extracellular water.