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. 2018 May 7;150(5):731–750. doi: 10.1085/jgp.201711965

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© 2018 Silverå Ejneby et al.

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Figure 6. — The valence of the charge is critical for the effect. (A) G(V) shifts for DHAA derivatives on the 3R Shaker K_V channel (100 µM, pH = 7.4). Mean ± SEM (n = 3–4 for Wu110 and Wu111, n = 5–6 for Wu161 and Wu109). (B) Effect of the uncharged Wu110 on the normalized G(V) curve of the 3R Shaker K_V channel. G(V) shift = 0.0 mV. (C) Effect of the permanently charged Wu161 on the normalized G(V) curve of the 3R Shaker K_V channel. G(V) shift = ‒34.6 mV.