Table 2. Summary of outcomes reported following aerosol infection with M. tuberculosis in Ifnar−/− mice.
| Mtb strain | Dose (CFU) | Mouse background | Bacterial loadsa | Lung pathologya | Survivala | Reference | |
|---|---|---|---|---|---|---|---|
| Lung | Spleen | ||||||
| H37Rv | 100 | C57BL/6 (R) | Increased (day 28 p.i.) | — | — | — | Antonelli et al., 2010 |
| H37Rv | 100–150 | C57BL/6 (R) | Decreased (day 28 p.i.) | — | — | — | Mayer-Barber et al., 2011 |
| H37Rv | 100 | C57BL/6 (R) | Transiently decreased (day 18 p.i.) but similar at day 25 p.i. | — | — | Similar (day 70 p.i.) | Desvignes et al., 2012 |
| H37Rv | 50–150 | C57BL/6 (R) | Similar (day 27 p.i.) | — | — | — | Redford et al., 2014 |
| H37Rv | 100–150 | C57BL/6 (R) | — | — | — | Similar (day 80 p.i.) | Mayer-Barber et al., 2014 |
| H37Rv | 500 (200 for survival) | C57BL/6 (R) | Decreased (day 42 p.i.) | — | — | Similar (day 80 p.i.) | Dorhoi et al., 2014 |
| 200 | 129S2 (S) | Decreased (day 21 p.i.) | — | Decreased (day 21 p.i.) | Increased | ||
| H37Rv | 50–100 | KO 129 (S); WT C57BL/6 (R) | Decreased (chronic phase, > day 75 p.i.) | — | — | — | Ordway et al., 2007 |
| Erdman | 106 (i.v.) | C57BL/6 (R) | Similar (days 10, 21 p.i.) | Decreased (days 10, 21 p.i.) | — | — | Stanley et al., 2007 |
| Erdman | 100 | C57BL/6 (R) | Transiently decreased (day 7 p.i.) but similar at days 21, 77, 100, 245 p.i. | Transiently decreased at day 77 p.i. but similar at other time points | Similar (days 100, 275 p.i.) | Increased | Kimmey et al., 2017 |
| Erdman | 100 | B6/129 (S) | Transiently increased (days 10, 20, 40 p.i.) but similar by day 80 p.i. | — | — | — | Cooper et al., 2000 |
| Erdman | 50–100 | KO 129 (S); WT C57BL/6 (R) | Decreased (> day 25 p.i.) | — | — | Similar (day 200 p.i.) | Ordway et al., 2007 |
| CSU93 | 50–100 | KO 129 (S); WT C57BL/6 (R) | Decreased (> day 25 p.i.) | — | — | Similar (day 200 p.i.) | Ordway et al., 2007 |
| HN878 | 100–200 | C57BL/6 (R) | Similar (days 28, 60 p.i.) | — | — | — | Moreira-Teixeira et al., 2017 |
| HN878 | 30 | C57BL/6 (R) | Similar (day 48 p.i.) | — | — | — | McNab et al., 2013 |
| HN878 | 100–200 | 129 (S) | — | — | — | Increased | Manca et al., 2005 |
| HN878 | 50–100 | KO 129 (S); WT C57BL/6 (R) | Decreased (> day 50 p.i.) | — | — | Similar (day 200 p.i.) | Ordway et al., 2007 |
| BTB 02-171 | 30 | C57BL/6 (R) | Similar (day 56 p.i.) | — | — | — | McNab et al., 2013 |
| BTB 02-171 | 100–200 | C57BL/6 (R) | Similar (days 20, 24, 27 p.i.) | — | Similar (day 27 p.i.) | Similar (> day 200 p.i.) | Moreira-Teixeira et al., 2016 |
Dashes indicate no data reported. Mtb, M. tuberculosis; p.i., postinfection; (R), M. tuberculosis–resistant mouse strain; (S), M. tuberculosis–susceptible mouse strain.
a
Compared with WT mice.