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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Gut. 2017 Mar 21;66(8):1414–1427. doi: 10.1136/gutjnl-2016-313099

Figure 5. CMC and P80 increase the pro-inflammatory potential of the mucosal-M-SHIME system microbiota.

Figure 5

A 9-vessel mucosal-M-SHIME system was set up and inoculated with fresh human feces at day −7. Following a 7-day stabilization period, vessels were treated with either water (N=2), CMC 1% (w/v, N=3) or P80 1% (v/v, N=3) for 13 days. (A) Luminal M-SHIME suspension FliC levels at days −7, −6, −3, −2, 1, 4, 6, 8, 11 and 13 days. (B) Luminal M-SHIME suspension was injected intraperitoneally to Rag−/− mice, and IL-6 were measured in the serum 2 h post-injection. Data are the means +/− S.E.M (N=3). Each treatment group was compared with the control group (water-treated) and statistical significance was determined using Student’s t test.