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. Author manuscript; available in PMC: 2018 Aug 1.
Published in final edited form as: Gut. 2017 Mar 21;66(8):1414–1427. doi: 10.1136/gutjnl-2016-313099

Figure 6. CMC and P80 increase the pro-inflammatory potential of the mucosal-M-SHIME system microbiota.

Figure 6

A 9-vessel mucosal-M-SHIME system was set up and inoculated with fresh human feces at day −11. Following an 11-day stabilization period, vessels were treated with either water, CMC (0.10%, 0.25%, 0.50% or 1.00%) or P80 (0.10%, 0.25%, 0.50% or 1.00%) for 10 days. (A–B) Luminal M-SHIME suspension LPS (A) and FliC (B) levels of CMC-treated M-SHIME at days −10, −7, −4, −2, 0, 1, 2, 3, 5, 7 and 10 days. (C–D) Luminal M-SHIME LPS (C) and FliC (D) levels of CMC- and P-80-treated M-SHIME at days −10, −7, −4, −2, 0, 1, 2, 3, 5, 7 and 10 days. Data are expressed as relative values with day −1 defined as 1 (N=1).