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Fraction of hypoxic (pimonidazole-positive) tissue (A), fraction of collagen-I-positive tissue (B), Ktrans (volume transfer constant of Gd-DOTA) (C), and ADC (apparent diffusion coefficient) (D) of early and late generation BK-12, ED-15, HL-16, and LA-19 tumors. Columns and bars: mean ± SE (n = 12–28).
