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. 2018 Apr 20;9(30):21478–21494. doi: 10.18632/oncotarget.25135

Figure 3. In vitro cell uptake analysis of cRGD-targeted PEG-PLGA nanoparticles compared to non-targeted PEG-PLGA nanoparticles in U87MG and Ln229 cells.

Figure 3

The nanoparticles were prepared with 10% Cy7.5-conjugated PLGA polymer. (A and B) represent the fluorescence image (magnification ×20), indicative of cellular uptake of nanoparticles. (C and D) Quantitative analysis of cellular uptake in U87MG and Ln229 cells, respectively, using Image J (n=5). The data are presented as mean ± SEM; * represents P ≤ 0.05, ** represents P ≤ 0.01 and *** represents P ≤ 0.001. (E and F) Flow cytometry (FACS) analysis of cellular uptake of nanoparticles in U87MG and Ln229 cells.