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. 2018 Apr 20;9(30):21100–21121. doi: 10.18632/oncotarget.24941

Table 1. The mutant-acquired PTEN−/− characteristics reversed by overexpression TPTE2.

Characteristic Relative levelb
MCF-10A PTEN−/− PTEN−/− TPTE2oe
Wound healing, +GFsa +++ ++++ ++
Wound healing, +S, –other GFsa ++ ++++ +
Wound healing, –GFsa
Division rate, +GFsa

++
++++
++++

++
Viability, on 2D substrate,
–GFsa, undisturbed
++++
Adhesion on 2D substrate
and long term viability, –GFsa
++++
Viability in 3D matrix,
–GFsa
++++
Expression of annexin V
surface binding site, +GFsa
+++ ++++

a +GFs: plus growth factors. +S, –other GFs: plus serum, minus growth factors.

b “Relative level” represents a comparison to the maximum measured amongst the three genotypes. Maximum is ++++, descending (+++, ++, +) to zero (−).