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. 2018 Apr 20;9(30):21141–21155. doi: 10.18632/oncotarget.24975

Figure 2. ABC transporters MDR1 and BCRP expression and activity are not significantly modified in resistance models.

Figure 2

(A) Surface expression of MDR1 and BCRP, studied by flow cytometry, does not show an increased expression of these ABC transporters in resistant cells. (B) Efflux activity was determined by Rhodamine 123 (Rho123) accumulation using flow cytometry. Rho123 efflux percent was not significantly different in resistant cells and in parental cells. The percentage of Rho123 efflux was calculated by comparing the mean fluorescence intensity (MFI) after uptakeand the MFI after efflux ((Uptake-Efflux)/Uptake*100).