Table 1. Subgroup analyses of relative risk of myocardial infarction associated with consumption of 1-2 cups, 2-3 cups, 3-4 cups, and over 4 cups of coffee per day in comparison with consumption of less than 1 cup per day (reference group), by sex, coffee type, study location, and study design.

	Coffee Consumption, cups/day
	1~2			2~3			3~4			> 4
	Number of estimates	OR	95% CI	Number of estimates	OR	95% CI	Number of estimates	OR	95% CI	Number of estimates	OR	95% CI
Sex
Men	8	1.16	0.96, 1.40	7	1.15	0.88, 1.50	8	1.75	1.44, 2.14	12	2.01	1.71, 2.36
Women	4	0.94	0.78, 1.14	6	0.91	0.74, 1.13	2	1.07	0.68, 1.68	6	0.91	0.67, 1.23
Both sexes	6	1.05	0.85, 1.31	6	1.00	0.87, 1.16	3	1.14	0.75, 1.74	8	1.35	1.14, 1.61
Coffee type
Caffeinated	4	0.96	0.70, 1.31	2	1.03	0.80, 1.33	2	1.23	0.71, 2.13	5	1.45	0.99, 2.12
Decaffeinated	3	1.15	0.81, 1.63	2	1.42	0.90, 2.25	2	1.42	0.82, 2.47	2	1.86	1.19, 2.90
All types	11	1.07	0.95, 1.21	11	1.03	0.86, 1.22	9	1.49	1.07, 2.07	14	1.46	1.13, 1.88
Study location
Europe	12	1.03	0.88, 1.22	13	1.02	0.87, 1.20	10	1.29	0.98, 1.71	13	1.32	1.02, 1.72
United States	5	1.15	0.96, 1.38	1	1.13	0.89, 1.43	3	1.68	1.29, 2.19	7	1.80	1.33, 2.45
Study design
Cohort	6	1.05	0.81, 1.36	4	0.87	0.72, 1.05	5	0.96	0.74, 1.24	10	1.19	0.91, 1.55
Case-control	12	1.08	0.95, 1.22	11	1.14	0.98, 1.32	8	1.68	1.41, 1.99	11	1.79	1.45, 2.20
NOS score
9	10	1.00	0.84, 1.19	10	1.09	0.91, 1.30	7	1.33	0.93, 1.90	10	1.24	0.93, 1.65
8	2	1.52	0.75, 3.10	0	-	-	2	1.69	0.53, 5.36	4	1.89	1.22, 2.93
7	6	1.14	0.98, 1.31	5	0.98	0.80, 1.20	4	1.54	1.23, 1.93	7	1.71	1.32, 2.22

OR = odds ratio, CI = confidential interval, NOS = Newcastle-Ottawa Scale.