Table 2. The comparison of basic characteristics and lipid profiles in low or high FIB4 group.
| Characteristics | Total | FIB4 <3.25 | FIB4 ≥3.25 | P value |
|---|---|---|---|---|
| Number of patients (%) | 863 | 553(64.1%) | 310(35.9%) | |
| Age (mean, SD) | 53.9±11.0 | 49.9±10.7 | 61.0±7.4 | 0.0001 |
|
Sex male female |
442(51.2%) 421(48.8%) |
322(58.2%) 231(41.8%) |
120(38.7%) 190(61.3%) |
0.0001* |
| HCV genotype (1b/others, %) | 358(41.5%)/505(58.5%) | 233(42.1%)/320(57.9%) | 125(40.3%)/185(59.7%) | 0.604* |
| HCV RNA (KIU/mL, SD) | 1296.9±2242.2 | 1509.2±2590.3 | 916.2±1340.0 | 0.0001 |
|
Viral response SVR Non SVR |
701(81.2%) 162(18.8%) |
466(84.3%) 87(15.7%) |
235(75.8%) 75(24.2%) |
0.002* |
| BMI (kg/m2) | 24.8±3.7 | 24.8±3.5 | 25.0±3.9 | 0.425 |
|
Diabetes Yes No |
137(16%) 719(84%) |
69(12.6%) 479(87.4%) |
68(22.1%) 240(77.9%) |
0.0001* |
|
Interleukin 28 beta TT Other |
536(62.1%) 327(37.9%) |
356(64.4%) 197(35.6%) |
180(58.1%) 130(41.9%) |
0.067* |
| GOT (U/l) | 94.0±58.1 | 73.4±40.1 | 130.9±66.5 | 0.0001 |
| GPT (U/l) | 137.5±92.7 | 124.3±85.8 | 161.1±99.8 | 0.0001 |
| GGT (U/l) | 60.6±58.6 | 54.6±55.2 | 71.5±63.0 | 0.0001 |
| PLT (109/l) | 169.8±62.4 | 197.0±58.1 | 121.4±34.1 | 0.0001 |
| AFP (ng/ml) | 17.4±119.0 | 9.3±25.3 | 31.0±191.3 | 0.015 |
| Triglycerides (mg/dl) | 91.1±34.9 | 89.7±35.4 | 93.6±33.9 | 0.111 |
| Cholesterol (mg/dl) | 166.8±31.1 | 167.9±32.1 | 164.9±29.0 | 0.179 |
| HDLC (mg/dl) | 45.7±14.4 | 45.9±15.1 | 45.3±12.9 | 0.510 |
| LDLC (mg/dl) | 97.9±27.9 | 99.3±28.4 | 95.4±26.6 | 0.047 |
*P value of Chi squared test, SVR – sustained virological response, BMI – body mass index, GOT – glutamic-oxaloacetic transaminase, GPT – glutamic-pyruvic transaminase, GGT – gamma-glutamyl transferase, PLT – platelet, AFP – alpha-fetoprotein, HDLC – high density lipoprotein, LDLC – low density lipoprotein, SD – standard deviation.