Table 4. Top 8 articles investigating therapies in patients that present with locally advanced pancreatic cancer (LAPC), ranked according to median overall survival (OS) achieved.

OS	Title	Reference	Patients	Phase	Randomization	R0 resection
29 months (arterial involvement), 42+ months (venous involvement)	Neoadjuvant gemcitabine, docetaxel, and capecitabine followed by gemcitabine and capecitabine/radiation therapy and surgery in locally advanced, unresectable pancreatic adenocarcinoma	Sherman et al. Cancer 2015	45	III	No	67% (arterial involvement), 73% (venous involvement)
26.6 months in LAPC	Final analysis of a phase II study of modified FOLFIRINOX in locally advanced and metastatic pancreatic cancer	Stein et al. Br J Cancer 2016	75	II	No	41.9%
12.3 months in all treated patients, 19.5 months with a dose of 1 mg/kg	Phase I Clinical Trial to Determine the Feasibility and Maximum Tolerated Dose of Panitumumab to Standard Gemcitabine-Based Chemoradiation in Locally Advanced Pancreatic Cancer	Van Zweeden et al. Clin Cancer Res 2015	14	I	No	Not determined
18.8 months	Baseline metabolic tumor volume and total lesion glycolysis are associated with survival outcomes in patients with locally advanced pancreatic cancer receiving stereotactic body radiation therapy	Dholakia et al. Int J Radiat Oncol Biol Phys 2014	32	II	No	Not determined
18.4 months LAPC, 14.4 months BRPC	The Role of Stereotactic Body Radiation Therapy for Pancreatic Cancer: A Single-Institution Experience.	Moningi et al. Ann Surg Oncol. 2015	88 (74 LAPC)		No	84% margin negative, 16% pathologic complete response

CRT indicates chemoradiotherapy, IC indicates induction chemotherapy, and BRPC indicates borderline resectable pancreatic cancer. Rates of achieving microscopic tumor clearance (R0) with resections are also displayed.