Table 1.
Epithelial differentiation markers in vagina and uterus and in heterotypic vaginal/uterine tissue recombinants prepared with mouse tissues.
| Vagina | VgM + UtE recombinants | Uterus | UtM + VgE recombinants | Reference |
|---|---|---|---|---|
| Stratified squamous | Stratified squamous | Simple columnar | Simple columnar | (Cunha, 1976) |
| Stratified mucifieda | Stratified mucifieda | N/A | N/A | (Cunha, 1976) |
| Trp63(+) | Trp63(+) | Trp63(−) | Trp63(−) | (Kurita and Cunha, 2001; Kurita et al., 2004) |
| Keratin 14(+) | Keratin 14(+) | Keratin 8/18 | Keratin 8/18 | (Kurita and Cunha, 2001) |
| Keratin 10(+)b | Keratin 10(+)b | Keratin 10(−) | Keratin 10(−) | (Buchanan et al., 1998) |
| Progesterone receptor negative following ovex. | Progesterone receptor negative following ovex. | Progesterone receptor positive following ovex. | Progesterone receptor positive following ovex. | (Kurita et al., 2001) |
| Progesterone receptor positive following ovex + E2 | Progesterone receptor positive following ovex + E2 | Progesterone receptor negative following ovex + E2 | Progesterone receptor negative following ovex + E2 | (Kurita et al., 2001) |
| Low molecular weight syndecan | Low molecular weight syndecan | High molecular weight syndecan | High molecular weight syndecan | (Boutin et al., 1991) |
Abbreviations: E2 = estradiol, ovex. = ovariectomy.
a
following a combination of estradiol plus progesterone.
b
following short-term estrogen treatment.