Table 3.
Differentiation markers in the human female fetal reproductive tract at 14–21 weeks of gestation.
| Uterine tube | Uterine corpus | Uterine cervix | Vagina | Bladder | Urethra | Introitus | |
|---|---|---|---|---|---|---|---|
| Epithelium | |||||||
| ESR1 | + + | −b | − | + | − | − | − |
| PR | − | −c | − | −, +g | − | − | − |
| AR | + | − | − | − | − | + | ND |
| KRT6 | − | − | − & +i | + + | + + | + + | + + |
| KRT7 | + + | + + | + + | − | + | + | − |
| KRT8 | + + | + + | + + | + a | + + | + + | − |
| KRT14 | − | − | −, −/+e | + + | + + | + + | + + |
| KRT10 | − | − | − | +h | − | − | + + |
| KRT19 | + | + | + + | + + & − | + + | + + | + + |
| TP63 | − | −d | + + | + + | + + | + + | + + |
| RUNX1 | − | + + | + + | + | + | + | − |
| Uroplakin | − | − | − | − | + | + | + |
| Mesenchyme | |||||||
| ESR1 | + | + | + | + | − | − | − |
| PR | − | − | − | + & − | − | − | − |
| AR | − | − | − | + | − | + | ND |
| α-actin | + | + + | + + | + | + + | + + | − |
| ISL1 | − | − | + | + + | − | − | ND |
| HOXA11 | − | + + | +/−f | − | − | − | − |
| Runx1 | − | − | −/+ | + | − | − | − |
a
apical epithelial cells only;
b
rare ESR1 patches in older specimens;
c
rare PGR patches in older specimens;
d
uterine fundus = negative;
e
exocervix = (−/+), endocervix = (−);
f
upper cervix, (positive), lower cervix (negative);
g
PR present at 18–21 weeks;
h
KRT10 only at 21 weeks;
i
KRT6 negative versus positive dependent on region; ND = not done.