Table 4.
Ontogeny of ESR1 in the human female fetal reproductive tract.
| Uterovaginal canal | Uterine tube | Ut-tube junct. | Uterine corpus | Uterine cervix | Vagina (with lumen) | |
|---|---|---|---|---|---|---|
| Epithelium | ||||||
| 8wks | − | − | NA | NA | NA | NA |
| 9wks | − | − | NA | NA | NA | NA |
| 11wks | − | − | NA | NA | NA | NA |
| 12wks | − | − | ND | − | − | NA |
| 13wks | − | − | − | − | − | NA |
| 14wks | NA | + | +/− | −/+ a | −/+ a | − |
| 16wks | NA | + | + | − | − | − |
| 18wks | NA | + | +/− | +/− | +/− | |
| 21wks | NA | ND | ND | + | −/+c | + |
| Mesenchymeb | ||||||
| 8wks | − | − | NA | NA | NA | NA |
| 9wks | − | − | NA | NA | NA | NA |
| 11wks | − | − | ND | NA | NA | NA |
| 12wks | + | ND | + | + | + | NA |
| 13wks | + | ND | ND | + | + | NA |
| 14wks | NA | + | ND | + | −/+ | NA |
| 16wks | NA | − | −/+ | + | + | −/+ |
| 18wks | NA | − | ND | + | −/+ | − |
| 21wks | NA | ND | ND | + | + | + |
a
rare ESR1-positivie cells.
b
= mesenchymal cells associated with epithelial structures as indicated.
c
Patchy expression; NA = Not applicable, ND = not done, Ut-tube junct. = uterotubal junction, wks = weeks.