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. Author manuscript; available in PMC: 2019 May 7.
Published in final edited form as: Curr Biol. 2018 Apr 19;28(9):1357–1369.e5. doi: 10.1016/j.cub.2018.03.025

Figure 6. Molecular pathways of CaSR signaling and regulation control acoustic decision-making.

Figure 6

(A) Diagram of ap2s1 alleles and motifs. See also Figure S7.

(B) Average relative startle bias of ap2s1p172 mutants.

(C) Average relative startle bias of 5 dpf wild type, ap2s1p172, CaSRp190, CaSRp190;ap2s1p172 double mutant larvae, at 25.9 dB. ****p<0.0001

(D) General model of acoustic sensorimotor decision-making: Hair cells and VIIIth statoacoustic nerve (green), Mauthner neurons (blue), spiral fiber neurons (violet), feedforward PHP inhibitory neurons (orange), spinal motor neurons (yellow), proposed LLC command neurons (red).

Error bars indicate SEM, significance by t-test.