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. Author manuscript; available in PMC: 2019 May 20.
Published in final edited form as: Free Radic Biol Med. 2018 Apr 4;120:317–329. doi: 10.1016/j.freeradbiomed.2018.04.002

Figure 4. Iron-selective chelation decreases HD-associated mitochondrial lipid peroxidation ex vivo.

Figure 4

Studies were completed on mitochondria isolated from 12 week-old R6/2 HD mice and wild-type controls. A. Steady-state lipid peroxidation product levels are increased in mitochondria purified from striata and cerebral cortices. B–C. In vitro mitochondrial lipid peroxide production rates are increased in HD mitochondria purified from striata (B) and cerebral cortices (C). Lipid peroxidation in striatal mitochondria is decreased by lipophilic iron chelation with [1 µM] DFP. P-values: *p < 0.05, **p < 0.01, ***p < 0.001.